Participant Information
| MCI (n = 17) | ||||
| Characteristic | HC (n = 16) | PiB− MCI (n = 4) | PiB+ MCI (n = 13) | AD (n = 8) |
| Sex | 10 M/6 F | 2 M/2 F | 7 M/6 F | 5 M/3 F |
| Age (y) | 51.1 (14.2) | 61.8 (7.5) | 62.0 (6.4) | 63.0 (6.5) |
| Education (y) | 11.1 (2.0) | 13.8 (2.2) | 13.7 (2.3) | 11.0 (2.3) |
| APOE4+ carriers (%) | 5 (31%) | 1 (25%) | 10 (77%)* | 6 (75%)* |
| Mini-Mental State Examination score | 28.9 (1.2) | 27.3 (2.1) | 27.8 (1.8) | 23.8 (5.7)† |
| Global cognition (z score) | 0.13 (0.66) | −0.31 (0.80) | −0.70 (0.95) | −2.07 (2.03)‡ |
| Episodic memory (z score) | −0.11 (0.48) | −1.20 (0.91) | −1.36 (0.72) | −2.25 (0.72)‡ |
| Cerebrospinal fluid data (pg/mL)¶ | ||||
| Aβ42 | 1160 (203) | 537 (148) | 506 (158) | |
| Total τ | 257 (46) | 404 (152) | 608 (321) | |
| Phospho τ | 55 (20) | 67 (16) | 93 (30) | |
↵* Significantly higher than HC (χ2 test).
↵† Significantly lower than HC (Mann–Whitney test).
↵‡ Global cognition and episodic memory z scores < −1.645 are considered outside cognitively normal reference range; neuropsychologic test description was previously reported (15).
↵¶ Cerebrospinal fluid data are considered abnormal for Aβ42 < 550 pg/mL, total τ > 400 pg/mL, and phospho τ > 60 pg/mL.
Values are means (SDs) or number (%).