TABLE 1

Clinicopathologic Characteristics According to Recurrence

CharacteristicOverallRecurrenceNonrecurrenceP
Patients (n)1103080
Sex (n)89 M:21 F24 M:6 F6 M:15 F0.882
Age, mean (y)54 ± 9 (range, 22–72)53 ± 12 (range, 22–72)55 ± 7 (range, 33–71)0.301
Follow-up time,  mean (mo)45.6 ± 18.0 (range, 7.4–83.1)22.9 ± 35.0 (range, 7.4–64.2)48.6 ± 55.0 (range, 27.5–83.1)<0.001
Viral status
 HBV86 (78%)22 (73%)64 (80%)
 HCV16 (15%)4 (13%)12 (15%)
 Neither HBV nor HCV8 (7%)4 (13%)4 (5%)
Pretransplantation  α-fetoprotein, median (ng/mL)22.2 (range, 1.0–1,708,000)141.9 (range, 1.0–1,708,000)15.2 (range, 1.5–1597)0.215
Donor (n)0.706
 LDLT93 (85%)26 (87%)67 (84%)
 DDLT17 (15%)4 (13%)13 (16%)
Tumor size, mean (cm)3.8 ± 3.66.6 ± 5.52.7 ± 1.60.001
Tumor number (n)0.011
 Single37 (34%)4 (13%)33 (41%)
 Multiple73 (66%)26 (87%)47 (59%)
Milan criteria (n)0.003
 Within55 (50%)8 (27%)47 (59%)
 Beyond55 (50%)22 (73%)33 (41%)
Tumor necrosis, mean (%)37.5 ± 41.841.6 ± 40.136.0 ± 42.60.535
Tumor grade (n)0.003
 1/245 (41%)5 (17%)40 (50%)
 3/465 (59%)25 (83%)40 (50%)
Vascular invasion (n)<0.001
 No84 (76%)14 (47%)70 (88%)
 Yes26 (24%)16 (53%)10 (13%)
T-stage (n)0.002
 T1/T245 (41%)5 (17%)40 (50%)
 T3/T465 (59%)25 (63%)40 (50%)
  • HBV = hepatitis B virus; HCV = hepatitis C virus; LDLT = living donor liver transplantation; DDLT = deceased donor liver transplantation.