Tumor Response Classifications of Lugano Criteria (2014)
| Classification | PET/CT-based criteria | CT-based criteria |
| Complete response | 1, 2, or 3 points on D5PS | >1.5 cm along longest transverse diameter |
| No new lesions | Regression of enlarged organs to normal size | |
| No bone marrow involvement | No new lesions | |
| No bone marrow involvement | ||
| Partial response | 4 or 5 points on D5PS | >50% reduction from baseline in sum of product of perpendicular diameters of up to 6 nodes |
| Reduced uptake compared with baseline | >50% reduction from baseline in size of enlarged spleen | |
| No new lesions | No new lesions | |
| Residual bone marrow uptake that is reduced from baseline | ||
| Stable disease | 4 or 5 points on D5PS | <50% reduction from baseline in sum of product of perpendicular diameters of up to 6 nodes |
| Unchanged uptake compared with baseline | No new lesions | |
| No new lesions | ||
| Unchanged bone marrow involvement | ||
| Progressive disease | 4 or 5 on D5PS | >50% increase in product of perpendicular diameters of node |
| Increased uptake compared with baseline | Increase in nodal diameter (by 0.5 cm if node is ≤2 cm, 1.0 cm if >2 cm) | |
| New or recurrent involvement in nodes and bone marrow demonstrated by 18F-FDG avidity | New or recurrent splenomegaly | |
| New or recurrent involvement of nodes and bone marrow |