TABLE 1

Radiation-Absorbed Doses to Tumor and Normal Organs in CD-1 Athymic Mice with Subcutaneous MDA-MB-468 Human BC Xenografts Injected Intratumorally with 4.5 MBq of 177Lu-T-AuNP or 177Lu-NT-AuNP

Radiation-absorbed dose (Gy)*
Organ177Lu-T-AuNP177Lu-NT-AuNP
Heart0.04 ± 0.030.06 ± 0.04
Lungs0.13 ± 0.110.15 ± 0.12
Liver0.91 ± 0.630.82 ± 0.49
Spleen0.64 ± 0.480.55 ± 0.40
Pancreas0.31 ± 0.130.25 ± 0.16
Kidneys0.11 ± 0.030.12 ± 0.05
Intestine0.06 ± 0.040.06 ± 0.04
Tumor30.37 ± 10.3621.86 ± 11.64
Total body0.35 ± 0.350.44 ± 0.39
  • * Cumulative radiation-absorbed dose from 0 h after injection to 48 h after injection of 177Lu-T-AuNP or 177Lu-NT-AuNP based on biodistribution data shown in Figure 2. Values represent mean ± SD (n = 4–8).