TABLE 2

Paired Label Biodistribution of 18F-SFB-5F7 and 125I-SGMIB-5F7 in Severe Combined Immunodeficiency Mice Bearing BT474M1 Xenografts

%ID/g*
1 h2 h
Tissue125I-SGMIB18F-SFB125I-SGMIB18F-SFB
Liver2.02 ± 0.470.95 ± 0.212.18 ± 0.550.68 ± 0.13
Spleen1.08 ± 0.330.67 ± 0.371.28 ± 0.220.52 ± 0.13
Lung2.96 ± 0.392.31 ± 0.402.56 ± 0.702.00 ± 0.38
Heart0.76 ± 0.200.62 ± 0.150.62 ± 0.130.54 ± 0.15
Kidney102.50 ± 26.353.90 ± 1.1393.00 ± 18.822.90 ± 0.77
Stomach1.32 ± 1.171.43 ± 1.691.98 ± 1.123.21 ± 4.62
Small intestine1.17 ± 0.550.69 ± 0.331.32 ± 0.460.59 ± 0.19
Large intestine1.18 ± 0.470.69 ± 0.503.86 ± 5.471.22 ± 1.66
Muscle1.14 ± 0.271.16 ± 0.371.21 ± 0.891.43 ± 1.20
Blood0.96 ± 0.261.25 ± 0.290.67 ± 0.511.44 ± 0.88
Bone0.88 ± 0.360.97 ± 0.550.51 ± 0.090.54 ± 0.08
Brain0.07 ± 0.020.09 ± 0.020.08 ± 0.050.12 ± 0.06
Tumor27.88 ± 8.0823.94 ± 7.0033.59 ± 6.2429.59 ± 5.10
  • * Mean ± SD (n = 5).

  • Difference in uptake not statistically significant.