TABLE 1

Hepatobiliary Secretion Kinetics Calculated for ¹¹C-CSar from PET Measurements

	k_backflux min⁻¹		k_BSEP min⁻¹		k_bile min⁻¹		K_int (mL blood/min/mL liver tissue)		K_sys (mL blood/min/mL liver tissue)
Pigs	Weighted mean	95% CI	Weighted mean	95% CI	Weighted mean	95% CI	Weighted mean	95% CI	Weighted mean	95% CI
Without CHD catheter	0.001	0.0008 to 0.0012	0.18	0.15 to 0.21	0.21	0.17 to 0.24	3.32	3.01 to 3.63	0.81	0.74 to 0.88
With CHD catheter	0.028^*	0.005 to 0.050	0.04^*	−0.01 to 0.08	0.09	0.04 to 0.14	0.65^*	−0.27 to 1.57	0.49	0.095 to 0.893