Overview for Main Study
| Mouse model | Age (mo) | 18F-GE180 small-animal PET (n) | 18F-GE180 small-animal PET (SUVRFBR/WM) | 18F-florbetaben small-animal PET (n) | 18F-florbetaben small-animal PET (SUVRFBR/WM) | 18F-FDG small-animal PET (n) | 18F-FDG small-animal PET (SUVRFBR/CBL) |
| PS2APP | 5 | 6 | 0.69 ± 0.03† | 6 | 0.80 ± 0.02 | 6 | 0.85 ± 0.05‡ |
| 8 | 5 | 0.72 ± 0.02‡ | 4 | 0.82 ± 0.03 | 4 | 0.90 ± 0.05‡ | |
| 13 | 8 | 0.81 ± 0.03‡ | 8 | 0.90 ± 0.02‡ | 8 | 0.94 ± 0.02‡ | |
| 16 | 8 | 0.83 ± 0.04‡ | 7 | 0.96 ± 0.03‡ | 7 | 0.91 ± 0.03* | |
| C57BL/6 | 5 | 8 | 0.63 ± 0.01 | 8 | 0.79 ± 0.01 | 8 | 0.77 ± 0.03 |
| 8 | 8 | 0.65 ± 0.03 | 8 | 0.79 ± 0.01 | 8 | 0.80 ± 0.03 | |
| 13 | 8 | 0.66 ± 0.02 | 8 | 0.78 ± 0.02 | 8 | 0.86 ± 0.04‡ | |
| 16 | 8 | 0.67 ± 0.02* | 8 | 0.78 ± 0.02 | 8 | 0.86 ± 0.04‡ |
Groups of PS2APP and C57BL/6 mice are provided together with forebrain small-animal PET SUVRs for the 3 radiotracers. Significant differences in PS2APP mice versus age-matched C57BL/6 control or significant differences in C57BL/6 controls against their 5-mo-old littermates are marked by *P < 0.05; †P < 0.01; ‡P < 0.001; 1-way ANOVA.