Regional Binding Parameters for 11C-UCB-J at Baseline and After Preblocking with Levetiracetam
| Preblocking VT with dose of levetiracetam* | ||||
| Brain region | Baseline VT (n = 5) | 10 mg/kg (n = 2) | 30 mg/kg (n = 1) | Bmax† (nmol/L) |
| Amygdala | 23.42 (1.3) | 11.89 (0.5) | 7.25 | 128 |
| Brain stem | 22.90 (2.0) | 11.83 (0.3) | 8.98 | 124 |
| Caudate | 43.39 (4.0) | 19.71 (0.2) | 11.53 | 276 |
| Cerebellum | 34.80 (3.8) | 15.85 (0.9) | 10.59 | 212 |
| Cingulate cortex | 53.41 (7.7) | 22.68 (0.6) | 12.79 | 350 |
| Frontal cortex | 52.96 (6.5) | 21.32 (0.3) | 11.49 | 347 |
| Globus pallidus | 27.13 (2.0) | 16.01 (0.6) | 11.3 | 155 |
| Insula | 52.45 (5.2) | 22.47 (0.3) | 12.97 | 343 |
| Nucleus accumbens | 51.63 (6.5) | 24.12 (1.2) | 13.39 | 337 |
| Occipital cortex | 50.85 (5.0) | 20.14 (0.1) | 11.8 | 331 |
| Pons | 22.78 (2.3) | 11.50 (0.7) | 9.3 | 123 |
| Putamen | 43.95 (1.9) | 20.40 (1.0) | 12.39 | 280 |
| Substantia nigra | 23.98 (2.2) | 12.60 (0.2) | 9.28 | 132 |
| Temporal cortex | 48.31 (4.9) | 20.35 (0.2) | 11.88 | 313 |
| Thalamus | 38.62 (4.8) | 18.56 (1.9) | 11.09 | 241 |