Survival by Exposure to Cytotoxic Agents (5-Fluorouracil, Oxaliplatin, or Irinotecan)
| Median | |||
| Interval (mo) | ≤2 drugs | All 3 drugs | P |
| From diagnosis of primary | 49.4 (40.1–58.7) (n = 222) | 47.5 (42.2–52.8) (n = 293) | 0.20 |
| From diagnosis of hepatic metastases | 37.2 (31.4–43.0) (n = 222) | 39.8 (35.5–44.1) (n = 294) | 0.36 |
| From first 90Y treatment | 14.7 (12.9–16.5) (n = 231) | 9.2 (7.8–10.6) (n = 295) | <0.001 |
| From hepatic metastases to 90Y | 10.9 (9.9–11.9) (n = 222) | 22.6 (20.5–24.7) (n = 294) | <0.001 |
| From 90Y (no extrahepatic metastases) | 16.5 (11.92–21.1) (n = 160) | 13.1 (10.0–16.2) (n = 164) | 0.007 |
| From 90Y (with extrahepatic metastases) | 9.6 (4.7–14.5) (n = 71) | 5.4 (3.9–7.0) (n = 131) | ≤0.003 |
Ranges in parentheses are 95% CI.