TABLE 3

Urine Clearance of 11C-Metformin, 51Cr-EDTA, Protein Binding, and Metabolites in Plasma from 2 Pigs

ParameterPig no. 5Pig no. 6
ClMET (mL/min)348, 388334
ClEDTA (mL/min)114, 11791
ClMET/ClEDTA3.05, 3.323.67
Protein binding (%)<0.5<0.5
MetabolitesNoneNone
  • ClMET = urine clearance of 11C-metformin; ClEDTA = urine clearance of 51Cr-EDTA = glomerular filtration rate.

  • Pigs underwent constant infusion clearance technique experiments.