Radiochemical Data from Preparation of N-11C-Methyl-Taurine–Conjugated Bile Acids
| Tracer | Radiochemical conversion* | Radiochemical yield† (not decay-corrected) | Radiochemical yield† (decay-corrected) | Isolated radioactivity‡ | Radiochemical purity¶ |
| 11C-MTCA | 78% ± 5% | 30% ± 4% | 71% ± 7% | 5.0–5.8 GBq | >99% |
| 11C-MTCDCA | 75% ± 4% | 26% ± 3% | 68% ± 4% | 4.7–6.4 GBq | >99% |
| 11C-MTDCA | 77% ± 2% | 25% ± 4% | 61% ± 8% | 2.2–6.2 GBq | >99% |
| 11C-MTUDCA | 77% ± 4% | 25% ± 3% | 66% ± 6% | 2.5–6.0 GBq | >99% |
| 11C-MTLCA | 77% ± 6% | 22% ± 1% | 65% ± 7% | 1.9–4.5 GBq | >99% |
↵* Radiochemical conversion (mean ± SD, n = 3–5) was estimated from LC-radio-MS analysis of crude reaction mixture.
↵† Radiochemical yield (mean ± SD, n = 3–5) is based on amount of isolated radioactivity after purification and relative to amount of 11C-methyl iodide initially trapped in reactor.
↵‡ Isolated radioactivity amount of purified product (n = 3–5).
↵¶ Radiochemical purity was determined by LC-radio-MS analysis of final product formulation (n = 3–5).