Comparison of Liposomal Uptake, Tumor Growth, and Morphology in High- Versus Low-Uptake Tumors
| Characteristic | High uptake (n = 9) | Low uptake (n = 17) | P |
| Liposomal uptake | |||
| Liposomes (in vivo) | 4.16 (3.67–5.01) | 2.12 (1.50–2.45) | <0.0001* |
| Liposomes (ex vivo) | 4.24 (3.95–7.06) | 2.26 (1.76–2.62) | <0.0001* |
| Time in days | 25 (21–43) | 70 (52–79) | 0.0104* |
| Morphological parameters | |||
| PEG percentage | 5.64 (4.92–11.77) | 2.50 (0.97–4.07) | 0.0018* |
| CD31 percentage | 2.84 (2.08–3.98) | 2.87 (2.12–5.57) | 0.5899 |
| Pimonidazole percentage | 37.13 (24.12–40.72) | 33.49 (27.23–45.19) | 0.6276 |
| Ki-67 percentage | 7.63 (5.32–9.21) | 7.79 (5.52–11.39) | 0.4188 |
| LYVE-1 percentage | 0.37 (0.15–0.79) | 0.21 (0.06–0.41) | 0.2465 |
| CD11b percentage | 1.01 (0.31–2.26) | 1.40 (0.39–2.53) | 0.4834 |
| Collagen percentage | 18.56 (12.23–20.23) | 13.72 (8.31–16.46) | 0.0524 |
↵* Significant at P level of less than 0.05.
Statistical test used was 2-tailed Mann–Whitney U test. Data are median, with interquartile ranges in parentheses.