Pig no. | Scan type | Purpose | Biologic sample evaluation |
1 | Whole-body baseline + postmetformin | Biodistribution + dosimetry | Plasma + urine metabolite |
2 | Dynamic PET/CT baseline | Pharmacokinetic | Plasma metabolite |
3 | Dynamic PET/CT baseline | Pharmacokinetic | Plasma metabolite |
4 | Dynamic PET/CT baseline + postmetformin | Pharmacokinetic | Plasma metabolite |
5 | Bolus + constant infusion | Renal clearance | Plasma protein binding, plasma + urine metabolite |
6 | Bolus + constant infusion | Renal clearance | Plasma protein binding, plasma + urine metabolite |