TABLE 1

Summary of Pigs Used

Pig no.Scan typePurposeBiologic sample evaluation
1Whole-body baseline + postmetforminBiodistribution + dosimetryPlasma + urine metabolite
2Dynamic PET/CT baselinePharmacokineticPlasma metabolite
3Dynamic PET/CT baselinePharmacokineticPlasma metabolite
4Dynamic PET/CT baseline + postmetforminPharmacokineticPlasma metabolite
5Bolus + constant infusionRenal clearancePlasma protein binding, plasma + urine metabolite
6Bolus + constant infusionRenal clearancePlasma protein binding, plasma + urine metabolite