TABLE 2

Pharmacokinetics of 11C-Metformin Before and After Competition with Unlabeled Metformin

ParameterBaselineUnlabeled metformin
K1 (mL/mL/min)1.540.67
k2 (min−1)0.220.15
Vd (mL per mL of plasma)*74.5
AUCcortex/AUCplasma†6.43.9
Cl(plasma — > urin) (mL/min)‡382179

  • ↵* Distribution volume Vd = K1/k2.

  • ↵† AUCcortex/AUCplasma determined at presumed steady state at 60 min after injection.

  • ↵‡ Urinary clearance Cl = k2 × Vcortex × AUCcortex/AUCplasma; with Vcortex = 2 × 115 mL.

  • AUC = area under the curve.