Autoradiographic Characteristics and Ki and Kd Values of THK Compounds
| THK no. | Autoradiography (tau/Aβ) | Ki (nM) | Kd (nM) |
| 523 | ++/− | 183 | − |
| 5377 | ++/− | 51.3 | − |
| 5378 | +/+ | 87.2 | − |
| 5140 | ++/+ | 54.8 | − |
| 5035 | −/− | 98.4 | − |
| 5156 | −/− | > 1,000 | − |
| 5107 | −/− | 142 | − |
| 5116 | −/− | 106 | − |
| 5117 | +++/− | 27.4 | 11.5 |
| 5105 | +++/+ | 10.1 | 4.40 |
| 5125 | +/− | 28.0 | 10.2 |
| 5151 | +++/− | 29.1 | 7.07 |
| 5129 | ++/+ | 17.5 | 3.14 |
| 5307 | +/− | 83.5 | 5.60 |
| 5287 | ++/− | 26.0 | 2.60 |
Symbols indicate results of binding intensities semiquantitatively analyzed by ARG-based binding assay. − indicates no binding of compound to tau or Aβ, + corresponds to weak binding, ++ corresponds to moderate binding, and +++ corresponds to strong binding.