Summary of Model Parameters
| Parameter | Amount/rate | Comments | Reference |
| Fluid | |||
| Plasma | 2.3 L | 36 mL/kg of body weight | (15) |
| Distribution volume in tissue | 5.9 L | 91 mL/kg of body weight | (16) |
| Administered intraperitoneal fluid | 1.7 L | ||
| Residual intraperitoneal fluid | 0.2 L | ||
| Intraperitoneal fluid transport | |||
| Lymphatic drainage (intraperitoneal fluid ⇒ plasma) | 0.3 mL/min | Mean delay, 5 h (±6 h; SD) | Model fit |
| Water reabsorption (intraperitoneal fluid ⇒ plasma) | 0.7 mL/min | Peritoneal fluid > 200 mL | Model fit |
| Water inflow at equilibrium (intraperitoneal fluid ⇐ plasma) | 0.3 mL/min | Peritoneal fluid = 200 mL | Model fit |
| Water inflow; osmotic effect (intraperitoneal fluid ⇐ plasma) | 3.1–1.5 mL/min | Proportional to intraperitoneal icodextran concentration, 0–24 h | Model fit |
| mAb conjugate transfer coefficients | |||
| TER (plasma ⇔ intercellular volume) | 0.065 h−1 | (17) | |
| Degradation/excretion (plasma ⇒ urine) | 0.0096–0.03 h−1 | Radiolabel-dependent | Model fit |
| mAb binding parameters | |||
| Association constant (intraperitoneal fluid ⇒ tumor cell) | 44,000 M−1 s−1 | (6) | |
| Dissociation constant (tumor cell ⇒ intraperitoneal fluid) | 0 s−1 | (6) | |
| Number of sites per cell | 700,000 | (6) |
TER = transcapillary escape rate.