Absorbed and Effective Doses of 68Ga-DOTA-E-[c(RGDfK)]2 in Healthy Subjects Using Different Urinary Bladder Models
| Men (n = 3) | Women (n = 2) | |||||
| Target organ | No voiding | 1-h voiding | 2.5-h voiding | No voiding | 1 h-voiding | 2.5-h voiding |
| Adrenals | 9.2 ± 0.6 | 9.1 ± 0.6 | 9.2 ± 0.6 | 12.0 ± 0.8 | 11.9 ± 0.8 | 12.0 ± 0.8 |
| Brain | 6.5 ± 0.5 | 6.5 ± 0.5 | 6.5 ± 0.5 | 8.2 ± 0.7 | 8.2 ± 0.7 | 8.2 ± 0.7 |
| Breasts | 6.6 ± 0.5 | 6.6 ± 0.5 | 6.6 ± 0.5 | 8.4 ± 0.9 | 8.4 ± 0.9 | 8.4 ± 0.9 |
| Gallbladder wall | 10.8 ± 0.7 | 10.7 ± 0.8 | 10.8 ± 0.8 | 14.1 ± 0.8 | 13.9 ± 0.9 | 14.1 ± 0.8 |
| Lower large intestine wall | 17.3 ± 0.6 | 14.7 ± 1.2 | 16.4 ± 1.3 | 22.0 ± 0.7 | 19.2 ± 0.1 | 21.6 ± 0.9 |
| Small intestine | 47.5 ± 5.2 | 46.5 ± 5.4 | 47.2 ± 5.3 | 64.3 ± 2.6 | 63.1 ± 2.4 | 64.1 ± 2.7 |
| Stomach wall | 8.9 ± 0.6 | 8.7 ± 0.6 | 8.8 ± 0.6 | 11.2 ± 0.9 | 11.1 ± 0.9 | 11.2 ± 0.9 |
| Upper large intestine wall | 36.2 ± 3.8 | 35.5 ± 3.9 | 36.0 ± 3.9 | 48.3 ± 1.6 | 47.4 ± 1.4 | 48.2 ± 1.7 |
| Heart wall | 8.0 ± 0.6 | 8.0 ± 0.6 | 8.0 ± 0.6 | 10.3 ± 1.1 | 10.3 ± 1.1 | 10.3 ± 1.1 |
| Kidneys | 53.9 ± 5.4 | 53.8 ± 5.3 | 53.9 ± 5.3 | 59.6 ± 16.5 | 59.4 ± 16.4 | 59.6 ± 16.5 |
| Liver | 26.6 ± 2.9 | 26.5 ± 2.9 | 26.5 ± 2.9 | 45.1 ± 1.6 | 45.0 ± 1.6 | 45.1 ± 1.6 |
| Lungs | 7.5 ± 0.6 | 7.5 ± 0.6 | 7.5 ± 0.6 | 9.7 ± 1.0 | 9.7 ± 1.0 | 9.7 ± 1.0 |
| Muscle | 8.4 ± 0.3 | 7.8 ± 0.6 | 8.2 ± 0.6 | 10.5 ± 0.6 | 9.8 ± 0.8 | 10.4 ± 0.6 |
| Ovaries* | 13.5 ± 0.2 | 11.1 ± 0.8 | 12.7 ± 1.0 | 17.3 ± 0.4 | 14.6 ± 0.3 | 17.0 ± 0.6 |
| Pancreas | 9.6 ± 0.6 | 9.5 ± 0.6 | 9.6 ± 0.6 | 12.2 ± 0.8 | 12.2 ± 0.9 | 12.2 ± 0.8 |
| Red marrow | 7.1 ± 0.3 | 6.7 ± 0.5 | 7.0 ± 0.5 | 8.8 ± 0.5 | 8.3 ± 0.6 | 8.7 ± 0.5 |
| Osteogenic cells | 10.7 ± 0.7 | 10.4 ± 0.8 | 10.6 ± 0.8 | 14.3 ± 1.4 | 14.1 ± 1.5 | 14.3 ± 1.4 |
| Skin | 6.7 ± 0.4 | 6.5 ± 0.5 | 6.7 ± 0.5 | 8.4 ± 0.8 | 8.1 ± 0.8 | 8.3 ± 0.8 |
| Spleen | 39.2 ± 5.5 | 39.1 ± 5.5 | 39.1 ± 5.5 | 47.1 ± 8.2 | 47.0 ± 8.2 | 47.1 ± 8.2 |
| Testes | 9.7 ± 0.1 | 8.0 ± 0.7 | 9.1 ± 0.8 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| Thymus | 7.3 ± 0.6 | 7.3 ± 0.6 | 7.3 ± 0.6 | 9.3 ± 1.0 | 9.3 ± 1.1 | 9.3 ± 1.1 |
| Thyroid | 16.5 ± 0.6 | 16.5 ± 0.6 | 16.5 ± 0.6 | 19.1 ± 2.5 | 19.1 ± 2.5 | 19.1 ± 2.5 |
| Urinary bladder wall | 363 ± 80 | 136 ± 30 | 285 ± 62 | 471 ± 121 | 206 ± 66 | 435 ± 140 |
| Uterus* | 18.1 ± 1.3 | 12.5 ± 1.1 | 16.2 ± 1.7 | 21.7 ± 1.7 | 16.1 ± 0.5 | 20.9 ± 2.0 |
| Total body | 9.8 ± 0.4 | 9.1 ± 0.7 | 9.6 ± 0.7 | 12.6 ± 0.5 | 11.9 ± 0.7 | 12.6 ± 0.5 |
| Effective dose (μSv/MBq) | 29.6 ± 3.7 | 17.4 ± 1.7 | 25.4 ± 3.3 | 38.5 ± 6.0 | 24.3 ± 3.1 | 36.6 ± 7.1 |
↵* Dosimetric calculations for men.
Data are mean ± SEM μGy/MBq.