TABLE 2

Dosimetry Calculations for Various 5B1-Based PET Imaging Strategies

Target organ*89Zr-DFO-5B1†64Cu-Tz-PEG7-NOTA pretargeting
Adrenals0.0600 (2.22)0.0021 (0.079)
Brain0.0459 (1.70)0.0022 (0.081)
Breasts0.0368 (1.36)0.0019 (0.071)
Gallbladder wall0.0576 (2.13)0.0022 (0.083)
Lower large intestine wall0.0600 (2.22)0.0040 (0.149)
Small intestine0.0568 (2.10)0.0025 (0.091)
Stomach wall0.0595 (2.20)0.0022 (0.081)
Upper large intestine wall0.0535 (1.98)0.0023 (0.086)
Heart wall0.0581 (2.15)0.0022 (0.081)
Kidneys0.0773 (2.86)0.0020 (0.073)
Liver0.0681 (2.52)0.0013 (0.047)
Lungs0.0681 (2.52)0.0011 (0.041)
Muscle0.0430 (1.59)0.0008 (0.031)
Ovaries0.0535 (1.98)0.0024 (0.087)
Pancreas0.0611 (2.26)0.0022 (0.083)
Red marrow0.1084 (4.01)0.0017 (0.064)
Osteogenic cells0.1373 (5.08)0.0047 (0.173)
Skin0.0316 (1.17)0.0018 (0.065)
Spleen0.1000 (3.70)0.0007 (0.025)
Testes0.0408 (1.51)0.0021 (0.076)
Thymus0.0462 (1.71)0.0020 (0.075)
Thyroid0.0457 (1.69)0.0021 (0.077)
Bladder wall0.0503 (1.86)0.0023 (0.086)
Uterus0.0538 (1.99)0.0024 (0.088)
Total body0.0503 (1.86)0.0021 (0.077)
Effective dose0.0546 (2.02)0.0021 (0.079)

  • ↵* Mean organ-absorbed doses and effective dose are expressed in rad/MBq and rem/MBq, respectively, with rad/mCi and rem/mCi, respectively, in parentheses.

  • ↵† Data originally reported in Viola-Villegas et al. (9).