In Vitro Data for 68Ga-Aquibeprin and 68Ga-Avebetrin
| IC50 [nM] | ||||
| Compound | αvβ3 | α5β1 | αIIbβ3 | logD |
| 68Ga/natGa-aquibeprin | 620 ± 23 | 0.083 ± 0.013 | >10,000 | −4.2 ± 0.1 |
| 68Ga/natGa-avebetrin | 0.22 ± 0.05 | 39 ± 10 | >10,000 | −3.9 ± 0.1* |
↵* Data taken from Notni et al. (31).
Data are integrin affinities (IC50, [nM]) and n-octanol–phosphate-buffered saline distribution coefficients (logD, pH 7.4) of Ga-labeled compounds, determined by enzyme-linked immune sorbent assay on immobilized integrins against vitronectin (αvβ3), fibronectin (α5β1), and fibrinogen (αIIbβ3).