TABLE 1

Biodistribution Data for 64Cu-NOTA-PEG7-Tz and 64Cu-NOTA-Tz

OrganTime after injection of 64Cu-NOTA-PEG7-Tz with lag time of 72 hTime after injection of 64Cu-NOTA-PEG7-Tz with lag time 48 h = 20 hTime after injection of 64Cu-NOTA-Tz with lag time of Lag time of 48 h = 20 h
4 h12 h20 h
Blood2.2 ± 0.31.9 ± 0.41.9 ± 0.31.4 ± 0.11.7 ± 0.3
Tumor3.2 ± 0.54.2 ± 2.48.2 ± 1.73.8 ± 0.57.1 ± 0.7
Heart0.68 ± 0.050.76 ± 0.200.77 ± 0.140.85 ± 0.031.0 ± 0.2
Lungs1.3 ± 0.21.2 ± 0.11.0 ± 0.71.1 ± 0.11.4 ± 0.3
Liver1.4 ± 0.11.3 ± 0.11.4 ± 0.12.7 ± 0.71.8 ± 0.2
Spleen0.59 ± 0.080.63 ± 0.070.73 ± 0.101.0 ± 0.30.80 ± 0.05
Pancreas0.30 ± 0.080.30 ± 0.080.40 ± 0.080.23 ± 0.140.24 ± 0.10
Stomach0.34 ± 0.090.22 ± 0.150.23 ± 0.030.73 ± 0.122.4 ± 1.2
Large intestine2.5 ± 0.50.91 ± 0.380.50 ± 0.100.51 ± 0.110.64 ± 0.03
Small intestine0.46 ± 0.080.42 ± 0.090.30 ± 0.062.7 ± 0.41.3 ± 0.1
Kidney1.9 ± 0.01.9 ± 0.11.8 ± 0.30.15 ± 0.010.20 ± 0.04
Muscle0.20 ± 0.030.16 ± 0.030.48 ± 0.400.26 ± 0.020.32 ± 0.05
Bone0.23 ± 0.040.25 ± 0.050.31 ± 0.070.55 ± 0.090.64 ± 0.11