TABLE 1

Categories of Biomarkers

CategoryPotential usesExamples in breast cancer
PrognosticDistinguish tumors with intrinsically good or poor prognosisER (4), HER2 (4), Oncotype DX 21-gene panel (23), circulating tumor cells (29)
PredictiveDetermine which therapies will be effective for individual patientER (13), HER2 (14)
PharmacodynamicDetermine dosing of novel systemic therapies for clinical trials18F-FES (84,85)