TABLE 1

A Summary of the Newer Generation of TSPO Radiotracers

Chemical classRadioligandBinding affinity
Indole acetamides11C-SSR180575
Vinca alkaloids11C-vinpocetine
Phenoxyarylacetamides11C-PBR282.2–52 nM in humans
18F-FEDAA1106
18F-PBR06
18F-FEPPA
11C-DAA1106<1 nM in humans
Imidazopyridine acetamides11C-DPA7131.3 nM in mice
18F-PBR111
Dihydro-9H-purinacetamides11C-DAC
11C-AC-5216
Pyrazolopyrimidines18F-DPA-714