TABLE 1

¹¹C-Metoclopramide Outcome Parameters Estimated in Rat Brain in Each Condition Using Logan Plot Analysis and 2-Tissue-Compartment Model

			Logan plot		2-tissue-compartment model
Condition	n	f_p (%)	V_T (mL⋅cm⁻³) using arterial input function	V’_T (mL⋅cm⁻³) using image-derived input function	K₁ (mL⋅cm⁻³⋅min⁻¹)	k₂ (min⁻¹)	k₃ (min⁻¹)	k₄ (min⁻¹)	BP_ND
A	5	12.0 ± 1.9	2.28 ± 0.32	2.46 ± 0.70	0.23 ± 0.11	0.35 ± 0.18	0.22 ± 0.12	0.09 ± 0.03	2.40 ± 0.78
B	4	14.8 ± 5.7	7.80 ± 1.43^*	8.33 ± 0.91^*	1.02 ± 0.34^*	0.66 ± 0.20	0.34 ± 0.09	0.06 ± 0.02	5.44 ± 0.50^*
C	4	12.4 ± 3.0	2.04 ± 0.19	2.41 ± 0.29	0.36 ± 0.12	0.43 ± 0.10	0.22 ± 0.15	0.09 ± 0.03	2.21 ± 1.04
D	5	16.7 ± 7.4	6.28 ± 0.48^†^,^‡	7.13 ± 0.35^†^,^¶	0.73 ± 0.11^†	0.20 ± 0.06^†^,^¶	0.10 ± 0.06^¶	0.07 ± 0.02	1.97 ± 0.40^¶

↵* Statistical significance, P < 0.05 for conditions B and C compared with condition A.
↵† Statistical significance, P < 0.05 for condition D compared with condition C.
↵¶ Statistical significance, P < 0.05, and ^‡P < 0.01 for condition D compared with condition B.
Data are shown as mean ± SD in each condition, n is number of animals used in each group, and f_P is percentage of free ¹¹C-metoclopramide in plasma. Logan plot analysis was used to estimate total distribution volume using arterial input function (V_T) or image-derived input function (V’_T). 2-tissue-compartment model was used to estimate ¹¹C-metoclopramide K₁, k₂, k₃, k₄, and BP_ND.