A-431 CD30-negative | Karpas 299 CD30-positive | ||||
Site | 24 h (n = 3) | 72 h (n = 3) | 24 h (n = 4) | 72 h (n = 3) | 72 h, blocking* (n = 3) |
Blood | 15.83 ± 2.27 | 12.23 ± 2.18 | 9.89 ± 2.70 | 6.38 ± 0.46 | 9.49 ± 2.60 |
Heart | 4.35 ± 1.27 | 3.11 ± 0.88 | 2.88 ± 0.36 | 1.71 ± 0.22 | 2.64 ± 0.47 |
Lung | 6.58 ± 1.15 | 5.81 ± 1.07 | 4.60 ± 0.87 | 3.63 ± 0.59 | 4.12 ± 1.20 |
Liver | 10.90 ± 2.10 | 12.61 ± 2.20 | 15.22 ± 1.71 | 11.78 ± 2.43 | 11.00 ± 2.32 |
Spleen | 7.20 ± 1.40 | 8.21 ± 2.87 | 8.78 ± 2.14 | 8.15 ± 0.79 | 7.07 ± 0.46 |
Pancreas | 1.68 ± 0.34 | 1.24 ± 0.30 | 1.05 ± 0.07 | 0.66 ± 0.06 | 0.74 ± 0.23 |
Stomach | 1.52 ± 0.40 | 1.49 ± 0.20 | 1.09 ± 0.17 | 0.83 ± 0.05 | 0.83 ± 0.08 |
Small intestine | 2.09 ± 0.44 | 1.82 ± 0.20 | 1.23 ± 0.20 | 1.12 ± 0.07 | 1.12 ± 0.36 |
Kidney | 6.55 ± 1.08 | 6.28 ± 0.99 | 9.41 ± 1.78 | 4.22 ± 0.51 | 4.95 ± 0.86 |
Muscle | 1.08 ± 0.19 | 0.91 ± 0.10 | 0.62 ± 0.06 | 0.49 ± 0.10 | 0.62 ± 0.20 |
Bone | 2.58 ± 0.53 | 4.11 ± 2.73 | 2.12 ± 0.48 | 5.06 ± 0.38 | 2.46 ± 0.65 |
Tumor | 8.23 ± 1.58 | 11.04 ± 0.40 | 27.21 ± 5.96 | 37.92 ± 8.22 | 22.54 ± 1.58 |
Tumor/blood | 0.52 ± 0.12 | 0.90 ± 0.16 | 2.75 ± 0.96 | 5.95 ± 1.36 | 2.37 ± 0.67 |
Tumor/liver | 0.76 ± 0.21 | 0.88 ± 0.16 | 1.79 ± 0.44 | 3.22 ± 0.96 | 2.05 ± 0.45 |
Tumor/kidney | 1.14 ± 0.31 | 1.34 ± 0.47 | 2.89 ± 0.84 | 9.00 ± 2.23 | 4.56 ± 0.85 |
Tumor/spleen | 1.26 ± 0.32 | 1.76 ± 0.28 | 3.10 ± 1.01 | 4.65 ± 1.10 | 3.19 ± 0.31 |
Tumor/muscle | 7.63 ± 2.00 | 12.09 ± 1.45 | 43.95 ± 10.67 | 77.24 ± 22.92 | 36.21 ± 11.85 |
Tumor/bone | 3.20 ± 0.90 | 2.68 ± 1.79 | 12.82 ± 4.03 | 7.49 ± 1.72 | 9.18 ± 2.51 |
↵* With 500-μg mAb blocking.
Data are mean %IA/g ± SD. Errors for tumor-to-tissue ratios are geometric mean of SD.