TABLE 1

Dogs Treated with 211At-Anti-CD45 Radioimmunotherapy

Dog no.Age (mo)Weight (kg)mAb dose* (mg/kg)211At activity (MBq/kg)Specific 211At activity (MBq/mg mAb)Autologous transplantSample time (h after injection)Transfusions (d after HCT)Survival (wk)
H573127.70.7514.619.5No22
H58599.40.7527.636.7No19
H5432012.80.7511.515.3Yes197, 11, 1948
H68978.70.7513.918.5Yes2, 19732
H5222211.80.7513.918.6Yes2846
H62989.51.0014.614.6Yes2, 196, 8, 1220
H6381012.31.0018.418.4Yes4, 196, 10, 14, 16, 19, 2232
H632108.41.0018.718.7Yes2, 197, 932
  • * Including 0.05 mg/kg of unlabeled mAb.

  • End of study.

  • Severe ascites.