Dogs Treated with 211At-Anti-CD45 Radioimmunotherapy
Dog no. | Age (mo) | Weight (kg) | mAb dose* (mg/kg) | 211At activity (MBq/kg) | Specific 211At activity (MBq/mg mAb) | Autologous transplant | Sample time (h after injection) | Transfusions (d after HCT) | Survival (wk) |
H573 | 12 | 7.7 | 0.75 | 14.6 | 19.5 | No | 22 | — | — |
H585 | 9 | 9.4 | 0.75 | 27.6 | 36.7 | No | 19 | — | — |
H543 | 20 | 12.8 | 0.75 | 11.5 | 15.3 | Yes | 19 | 7, 11, 19 | 48† |
H689 | 7 | 8.7 | 0.75 | 13.9 | 18.5 | Yes | 2, 19 | 7 | 32† |
H522 | 22 | 11.8 | 0.75 | 13.9 | 18.6 | Yes | 2 | 8 | 46† |
H629 | 8 | 9.5 | 1.00 | 14.6 | 14.6 | Yes | 2, 19 | 6, 8, 12 | 20‡ |
H638 | 10 | 12.3 | 1.00 | 18.4 | 18.4 | Yes | 4, 19 | 6, 10, 14, 16, 19, 22 | 32† |
H632 | 10 | 8.4 | 1.00 | 18.7 | 18.7 | Yes | 2, 19 | 7, 9 | 32† |