TABLE 3

Per-Lesion Analysis (Breast and Prostate Cancers)

Lesion type	Examination	Sensitivity	Specificity	PPV	NPV	Accuracy
Extraskeletal lesions	¹⁸F⁻/¹⁸F-FDG PET/CT	92.9	0.0	81.3	0.0	76.5
	Whole-body MRI	92.9	33.3	86.7	50.0	82.4
	¹⁸F⁻/¹⁸F-FDG PET/CT + whole-body MRI	100.0	0.0	82.4	NA	82.4
Skeletal lesions	¹⁸F⁻/¹⁸F-FDG PET/CT	96.2*^†	33.3	93.7	50.0	89.8^‡§
	Whole-body MRI	81.4	22.2	89.1	13.3	74.7
	Bone scintigraphy	64.6	77.8	96.2	20.0	65.9
	Bone scintigraphy + whole-body MRI	91.4	22.2	90.1	25.0	83.5
	¹⁸F⁻/¹⁸F-FDG PET/CT + whole-body MRI	100.0	0.0	89.8	NA	89.8
Osteolytic lesions	¹⁸F⁻/¹⁸F-FDG PET/CT	100.0	0.0	83.3	NA	83.3
	Whole-body MRI	100.0	0.0	83.3	NA	83.3
	Bone scintigraphy	80.0	100.0	100.0	50.0	83.3
	Bone scintigraphy + whole-body MRI	100.0	0.0	83.3	NA	83.3
	¹⁸F⁻/¹⁸F-FDG PET/CT + whole-body MRI	100.0	0.0	83.3	NA	83.3
Osteoblastic lesions	¹⁸F⁻/¹⁸F-FDG PET/CT	95.9*^†\|\|	37.5	93.4	50.0	90.2^§¶
	Whole-body MRI	80.0	25.0	89.7	13.3	74.0
	Bone scintigraphy	63.5	75.0	95.9	18.2	64.6
	Bone scintigraphy + whole-body MRI	90.8	25.0	90.8	25.0	83.6
	¹⁸F⁻/¹⁸F-FDG PET/CT + whole-body MRI	100.0	0.0	90.2	NA	90.2
Total lesions	¹⁸F⁻/¹⁸F-FDG PET/CT	95.7^#	25.0	90.8	42.9	87.6**
	Whole-body MRI	83.3	25.0	88.6	17.6	76.0
	Bone scintigraphy + whole-body MRI	91.6	25.0	89.5	30.0	83.3
	¹⁸F⁻/¹⁸F-FDG PET/CT + whole-body MRI	100.0	0.0	87.5	NA	87.5

NA = not applicable. ¹⁸F⁻/¹⁸F-FDG PET/CT showed significantly higher sensitivity (*P < 0.001,^#P < 0.002) and accuracy (^‡P < 0.02, **P < 0.02, ^¶P < 0.05) than whole-body MRI. ¹⁸F⁻/¹⁸F-FDG PET/CT showed higher sensitivity (^†P < 0.001) and accuracy (^§P < 0.001) than bone scintigraphy. ¹⁸F⁻/¹⁸F-FDG PET/CT showed lower sensitivity than combination of ¹⁸F⁻/¹⁸F-FDG PET/CT and whole-body MRI (^||P = 0.01).