TABLE 2

Relationship Between mcSUVr and Pathology Data

	mcSUVr
Autopsy measure	Whole cerebellum	Cerebellar gray matter	Pons	Centrum semiovale
Global highest neuritic plaque count	0.71	0.68	0.68	0.71
Immunohistochemistry Aβ burden	0.75	0.71	0.72	0.70
CERAD score (0- to 3-point scale)	0.73	0.70	0.71	0.73
AUC and 95% confidence interval	0.996 (0.988–1.000)	0.980 (0.953–1.000)	0.965 (0.921–1.000)	0.951 (0.904–0.999)
Cohen d (weighted variance)	2.77	2.37	2.83	2.24
Coefficient of variance from 74 YCNs	0.042	0.079	0.059	0.053

Data are Spearman rank correlations between mcSUVr and autopsy measures. All correlations were significant (P < 0.0001). Cohen d was calculated using weighted pooled variance estimation from pathology-positive and -negative groups as classified on autopsy measures. AUCs were calculated from ROC analyses intended to discriminate pathology-positive and -negative groups using 4 mcSUVr reference regions (Supplemental Fig. 2)