Results of Patients Not Receiving Therapeutic Dose Because of Altered Biodistribution
| Assessment by treatment site | Assessment by independent review | |||
| Patient no. | Biodistribution by visual inspection of γ images | TBRT (h) | Visual assessment of γ-camera images | Biodistribution result |
| 1 | Unknown* | 45 | Day 0: Most activity in blood pool, and uptake in normal liver and spleen less than in heart | Altered |
| Day 4: Blood pool not visualized; diffuse, increased uptake in liver and spleen | ||||
| Day 7: Altered biodistribution best appreciated by comparison of 3 image sets | ||||
| 2 | Altered by lung uptake | 154 | Day 0: Most activity in blood pool; uptake in normal liver and spleen less than in heart | Expected |
| Day 2: Most activity in blood pool; uptake in normal liver and spleen less than in heart | ||||
| Day 6: Most activity in blood pool; uptake in normal liver and spleen less than in heart; normal biodistribution best visualized on day 0 | ||||
| 3 | Altered by lung uptake | 101 | Day 0: Most activity in blood pool; uptake in normal liver and spleen less than in heart | Expected |
| Day 3: Most activity in blood pool; uptake in normal liver and spleen less than in heart; tumor targeting | ||||
| Day 6: Most activity in blood pool; uptake in normal liver and spleen less than in heart; tumor targeting; normal biodistribution best visualized on day 3 | ||||
| 4 | Altered by stomach uptake | NR | NA | — |
| 5 | Altered by lung uptake | NR | NA | — |
↵* Deemed to have altered biodistribution because of TBRT of 45 h.
NR = not reported; NA = not available.