Patient no. | Age (y) | Sex | Location | WHO grade | Before therapy | Octreotide uptake | Fractions/MBq | Karnofsky performance status | Response (RECIST) | PFS/OS (mo) |
Treatment category 1* | ||||||||||
1 | 63 | M | Falx bifrontal | II | S, RT | NA | 2/1,688 | 80 | PD | 0/12 |
2 | 63 | F | Skull base + parietal | I | S | 2 | 3/4,500 | 90 | SD | 137+/137+ |
3 | 51 | F | Convexity, multiple | III | S, RT, C | 3 | 4/8,438 | 90 | PD | 4/22 |
4 | 56 | F | Skull base | I | S | 3 | 2/13,500 | 90 | SD | 87+/87+ |
5 | 44 | M | Skull base | I | S, RT | 3 | 2/14,800 | 90 | SD | 17/48+ |
6 | 46 | F | Skull base | I | S | 1 | 2/12,580 | 80 | SD | 24+/24+ |
7 | 47 | F | Skull base | I | S | 3 | 2/12,950 | 80 | SD | 72+/72+ |
8 | 67 | M | Convexity, multiple | I | S, RT | 2 | 2/13,320 | 60 | SD | 19/32 |
9 | 56 | F | Skull base | I | S | 2 | 2/11,840 | 100 | SD | 14+/14+ |
Treatment category 2† | ||||||||||
10 | 54 | F | Skull base | II | — | 2 | 2/13,320 | 90 | SD | 83+/83+ |
11 | 64 | F | Skull base + temporal | NA | — | 3 | 2/14,800 | 90 | SD | 68+/68+ |
12 | 43 | F | Skull base | NA | — | 2 | 2/13,690 | 90 | SD | 56+/56+ |
13 | 41 | F | Pineal region | I | — | 3 | 2/11,250 | 50 | SD | 57/57 |
14 | 71 | F | Skull base + parietal | NA | — | 3 | 2/12,210 | 80 | SD | 18/18 |
15 | 78 | F | Skull base | I | S | 1 | 2/13,320 | 70 | SD | 14/16 |
↵* Treatment after subtotal surgery and other pretreatment/diffuse tumor growth.
↵† Treatment due to severe medical comorbidity/refusal of surgical tumor resection.
Age = at initiation of 90Y-DOTATOC; RECIST = Response Evaluation Criteria In Solid Tumors; S = surgery; RT = radiotherapy; NA = not applicable; PD = progressive disease; SD = stable disease; + = ongoing; multiple = ≥3 tumor locations; C = chemotherapy.