TABLE 1

Associations of GRPR, SSTR2, and CXCR4 mRNA Levels in LNN M0 Patients

			GRPR mRNA (x10⁻²)		SSTR2 mRNA (x10⁻²)		CXCR4 mRNA (x10⁻²)
Characteristic	No. of patients^*	Percentage of patients	Median	Interquartile range	Median	Interquartile range	Median	Interquartile range
All patients in this cohort	684	100%	0.72	7.07	0.58	1.75	11.78	13.13
Age at surgery (y)
≤40	60	9%	1.17	12.72	0.90	2.99	14.06	13.75
41–55	252	37%	0.97	9.20	0.61	1.64	11.58	13.18
56–70	218	32%	0.52	5.38	0.52	1.68	12.19	11.34
>70	154	23%	0.72	4.44	0.62	1.61	9.99	12.98
P^†			0.52		0.68		0.0403
Menopausal status
Premenopausal	273	40%	1.26	10.95	0.62	1.82	11.81	13.73
Postmenopausal	411	60%	0.60	4.87	0.55	1.57	11.76	12.12
P^†			0.13		0.53		0.39
Surgery
Lumpectomy	378	55%	0.61	7.69	0.57	1.82	11.67	13.15
Ablation	306	45%	0.90	6.79	0.60	1.56	11.90	13.00
P^†			0.69		0.59		0.65
Pathologic tumor size
pT1	307	45%	1.25	8.54	0.69	1.87	12.03	13.40
pT2 + unknown	351	51%	0.41	5.25	0.51	1.65	11.53	12.84
pT3 + pT4	26	4%	0.58	3.05	0.50	1.38	12.19	13.53
P^†			0.0014		0.24		0.92
ESR1 mRNA status^‡
Negative < 0.2	184	27%	0.09	0.13	0.28	0.42	14.74	13.83
Positive ≥ 0.2	500	73%	2.46	10.98	0.81	2.59	10.98	12.16
P^‡			<0.001		<0.001		<0.001
PGR mRNA status^‡
Negative < 0.1	285	42%	0.12	0.32	0.32	0.56	14.36	14.31
Positive ≥ 0.1	399	58%	3.67	12.68	1.02	2.98	10.45	11.09
P^‡			< 0.001		<0.001		<0.001
ERBB2 mRNA status^‡
Negative < 18	574	84%	0.99	8.28	0.61	1.92	11.64	12.96
Positive ≥ 18	107	16%	0.30	1.51	0.49	1.00	13.88	13.32
P^¶			<0.001		0.0344		0.22
Grade (GGI)
1	227	33%	2.42	10.46	0.75	2.11	10.83	11.03
2	229	33%	0.89	6.92	0.63	2.41	11.44	14.59
3	224	33%	0.13	1.42	0.34	0.98	13.83	13.58
P^¶			<0.001		<0.001		<0.001
Percentage invasive tumor cells
≤70%	470	69%	0.81	6.84	0.63	1.88	12.57	13.92
>70%	214	31%	0.64	8.28	0.43	1.28	9.13	10.70
P^†			0.87		0.002		<0.001

↵* Because of missing numbers, not all categories add up to 684.
↵† P for Mann–Whitney U or Kruskal–Wallis test when appropriate.
↵‡ ESR1, PGR, and ERBB2 were determined by real-time PCR; cut points were as follows: ESR1 = 0.2, PGR = 0.1, and ERBB2 = 18.0 (mRNA level relative to reference gene set).
↵¶ P for Spearman rank-correlation test.