Unifactor Analysis of Possible Prognostic Factors for OS and Analysis Adjusted by Time Between Radiotherapy and PET Assessment
| Variable | n | 2-y OS % (95% CI) | Hazard ratio (95% CI) | P | Adjusted hazard ratio (95% CI) | Adjusted P |
| Chemotherapy | 0.75 | 0.94 | ||||
| No | 24 | 54 (38–78) | 1 | 1 | ||
| Yes | 13 | 62 (40–95) | 0.85 (0.33–2.23) | 0.96 (0.35–2.60) | ||
| Concomitant surgery* | 0.24 | 0.28 | ||||
| No | 7 | 43 (18–100) | 1 | 1 | ||
| Yes | 24 | 63 (46–85) | 0.53 (0.18–1.54) | 0.55 (0.19–1.61) | ||
| Nodal involvement† | <0.001 | 0.016 | ||||
| No | 9 | 100 | 1 | 1 | ||
| Yes | 27 | 44 (29–68) | 10.3 (1.4–77.3) | 12.3 (1.6–95.8) | ||
| Size | 0.17 | 0.22 | ||||
| ≤2 cm | 21 | 57 (40–83) | 1 | 1 | ||
| >2 cm | 10 | 40 (19–86) | 1.90 (0.75–4.82) | 1.90 (0.68–5.32) | ||
| Site | 0.40 | 0.47 | ||||
| Head and neck | 15 | 53 (33–86) | 1 | 1 | ||
| Lower limb | 13 | 77 (57–100) | 0.60 (0.21–1.74) | 0.65 (0.22–1.91) | ||
| Upper limb/trunk | 9 | 33 (13–84) | 1.27 (0.44–3.68) | 1.31 (0.45–3.80) | ||
| Positive resection margin | 0.17 | 0.19 | ||||
| No | 11 | 64 (41–100) | 1 | 1 | ||
| Yes | 19 | 47 (30–76) | 2.08 (0.72–5.98) | 2.01 (0.70–5.80) | ||
| Age | 37 | 1.0 (0.97–1.04) | 0.92 | 1.0 (0.97–1.05) | 0.73 | |
| Metabolic response‡ | <0.001 | <0.001 | ||||
| CMR | 24 | 88 (75–100) | 1 | 1 | ||
| Non-CMR | 13 | — | 25.7 (6.8–96.5) | 28.8 (7.1–117.3) |