TABLE 4

Comparison of Some Kinetic Parameters for ¹¹C-Phenytoin, (R)-¹¹C-Verapamil, and ¹¹C-dLop

Pgp substrate	K₁ (mL·mL⁻¹·min⁻¹)	k₂ (min⁻¹)	V_T (mL·mL⁻¹)
¹¹C-phenytoin (n = 6)^*^†	0.037 ± 0.008	0.042 ± 0.009	0.881 ± 0.126
(R)-¹¹C-verapamil (n = 5)^‡	0.036 ± 0.009	0.102 ± 0.003	0.660 ± 0.123
¹¹C-dLop (n = 6)^*	0.014 ± 0.001	0.012 ± 0.002	1.169 ± 0.149

↵* Obtained using 1T2k + V_b model.
↵† Pooled over whole-brain region across all subjects.
↵‡ Obtained using 2T4k model.
Data are mean ± SD.