Quantitation of PET Images (n = 1 or 2) for 124I- and 89Zr-Labeled αHER2 Fab-PAS200
89Zr⋅Df-Fab-PAS200 | 124I-Fab-PAS200 | ||||||
Parameter | 6 h | 24 h | 48 h | 72 h | 6 h | 24 h | 120 h |
%ID/g in tissue | |||||||
Tumor | 10 | 13 | 10 | 6.2 | 6.8 | 2.4 | 0.4 |
Muscle | 1.7 | 0.8 | 0.9 | 0.6 | 0.7 | 0.2 | 0.004 |
Liver | 9.4 | 7.6 | 5.1 | 3.7 | 3.7 | 1.5 | 0.1 |
Kidney | 62 | 62 | 56 | 34 | 3.4 | 0.9 | 0.03 |
Tumor-to-muscle ratio | 6.2 | 17 | 11 | 9.8 | 9.7 | 15.7 | 85 |