TABLE 1

Biodistribution of ⁶⁴Cu-FBP8 in Healthy Rats

Organ	5 min	30 min	3 h	6 h	24 h
Liver	7.385 ± 0.838	5.820 ± 0.479	1.175 ± 0.276	1.390 ± 0.079	0.259 ± 0.032
Kidneys	19.787 ± 1.694	20.520 ± 6.655	14.908 ± 3.386	11.663 ± 1.466	2.946 ± 0.796
Lungs	0.961 ± 0.159	0.471 ± 0.075	0.038 ± 0.007	0.053 ± 0.008	0.009 ± 0.001
Spleen	0.261 ± 0.046	0.192 ± 0.040	0.019 ± 0.002	0.028 ± 0.008	0.006 ± 0.001
Bladder	0.078 ± 0.030	0.193 ± 0.087	0.010 ± 0.005	0.005 ± 0.001	0.0008 ± 0.0002
Heart	0.321 ± 0.026	0.159 ± 0.023	0.013 ± 0.002	0.018 ± 0.003	0.006 ± 0.001
Brain	0.055 ± 0.012	0.037 ± 0.004	0.004 ± 0.001	0.005 ± 0.001	0.002 ± 0.001
Adrenals	0.036 ± 0.009	0.018 ± 0.005	0.003 ± 0.001	0.004 ± 0.003	0.0009 ± 0.0003
Stomach	0.722 ± 0.096	0.441 ± 0.055	0.058 ± 0.013	0.068 ± 0.010	0.012 ± 0.002
Small intestine	1.854 ± 0.462	1.390 ± 0.311	0.255 ± 0.153	0.204 ± 0.077	0.054 ± 0.012
Uterus	0.423 ± 0.161	0.196 ± 0.027	0.024 ± 0.012	0.029 ± 0.005	0.005 ± 0.001
Ovaries	0.070 ± 0.013	0.039 ± 0.008	0.005 ± 0.001	0.007 ± 0.002	0.0013 ± 0.0001
Blood	16.046 ± 2.363	7.076 ± 1.611	0.378 ± 0.062	0.542 ± 0.057	0.123 ± 0.019
Muscle	14.412 ± 2.549	10.222 ± 3.781	0.807 ± 0.138	0.891 ± 0.367	0.248 ± 0.056
Fat	1.473 ± 0.685	0.856 ± 0.158	0.154 ± 0.113	0.052 ± 0.019	0.013 ± 0.003
Bone	3.184 ± 0.658	1.784 ± 0.312	0.401 ± 0.240	0.372 ± 0.081	0.095 ± 0.018

Data are group mean of percentage injected activity (dose) per organ ± SD. Data are reported without applying decay correction. n = 6/group (3 males and 3 females); data for ovaries and uterus are n = 3/group.