TABLE 1

Characteristics of Somatostatin Receptor Radiotracers

Characteristic	¹¹¹In-DTPA-OC	⁶⁸Ga-DOTATATE, ⁶⁸Ga-DOTATOC, ⁶⁸Ga-DOTANOC	⁶⁴Cu-DOTATATE
Radionuclide from	Cyclotron	Generator	Cyclotron
Physical half-life	2.8 d	68 min	12.7 h
Positron range
Mean in water	—	≈3 mm	<1 mm
Maximum in water	—	≈8 mm	≈3 mm
Radiation dosimetry^*	5.6–11.1 mSv	2.0–5.1 mSv	5.7–6.9 mSv
Tracer labeling	Locally (kit)	Locally	Centrally (or locally)
Shelf life of labeled compound^†	6 h	3 h	24 h
Delayed imaging (>3 h)	Possible	Not possible	Possible

↵* From Johnbeck et al. (36).
↵† ¹¹¹In-DTPA-OC: according to manufacturer’s instruction; ⁶⁸Ga: limited by half-life of isotope to obtain 1 patient dose (new generator); and ⁶⁴Cu-DOTATATE: as approved by Danish Health and Medicines Authority.