Baseline Characteristics of the 3 TSPO Genotypes
| Amyloid-positive | Scores | ||||||||||
| Genotype | n | Male (%) | Age* (y) | % | n | ApoE4 | MMSE* | ADAS-Cog* | ADAS-Mod* | CDR* | GDS* |
| Thr/Thr | 68 | 60.2 | 76.6 ± 6.1 | 62.5 | 24 | 16.2 | 26.7 ± 2.7 | 11.8 ± 7.0 | 18.2 ± 10.5 | 0.41 ± 0.32 | 1.5 ± 1.5 |
| Ala/Thr | 329 | 56.2 | 75.2 ± 6.7 | 52.2 | 113 | 8.5 | 26.8 ± 2.7 | 11.7 ± 6.5 | 18.3 ± 9.6 | 0.40 ± 0.30 | 1.3 ± 1.3 |
| Ala/Ala | 401 | 59.1 | 75.2 ± 7.0 | 50.8 | 118 | 11.5 | 26.7 ± 2.6 | 11.6 ± 6.3 | 18.1 ± 9.2 | 0.42 ± 0.29 | 1.5 ± 1.4 |
| Total | 798 | 58.0 | 75.3 ± 6.8 | 52.5 | 255 | 10.7 | 26.7 ± 2.7 | 11.6 ± 6.4 | 18.1 ± 9.5 | 0.41 ± 0.30 | 1.4 ± 1.4 |
| P | >>0.05 | >>0.05 | >>0.05 | >0.05 | >>0.05 | >>0.05 | >>0.05 | >>0.05 | >0.05 | ||
↵* Data are mean ± SD.
ApoE4 = ApoE4/ApoE4 homozygous.
Amyloid PET scan was performed on only 255 patients, and percentage reported was calculated for this subgroup.