Study | Design | Data collection | Sample size | FIGO stage | Tracer and dosing | Tracer injection technique | SPECT/CT | Lymphoscintigraphy | Moment of imaging | Intraoperative SLN procedure |
Pandit (26) | Prospective | Paired | 10 | Not specified | 37–144 MBq 99mTc-sulfur colloid | 2 quadrant | SPECT and low-dose CT, <60 min pi | Dynamic and anterior + lateral static, directly pi | Preoperative day or day of surgery | Laparotomy or laparoscopy (with blue dye) |
Diaz (3) | Prospective | Paired | 22 | IB1–IIA | 144 MBq 99mTc-albumin nanocolloid | 4 quadrant | SPECT and CT of unknown dosing, 120–240 min pi | Dynamic and 4-directional static, 30–240 min pi | Preoperative day | Laparotomy or laparoscopy (with blue dye) |
Kraft (8) | Retrospective | Paired | 36 | IA1–II | 40 MBq 99mTc-nanocolloid | 4 quadrant | SPECT and low-dose CT, directly after lymphoscintigraphy | Anterior and posterior static, 25–60 min pi | Day of surgery | Not specified (with blue dye) |
Buda (27) | Retrospective | Paired | 10 | IA2–IB1 | 30–44 MBq 99mTc-albumin nanocolloid | 4 quadrant | SPECT and low-dose CT, 180 min pi | Dynamic and anterior static, directly and 180 min pi | Preoperative day or day of surgery | Laparotomy or laparoscopy (with blue dye) |
Hoogendam (4) | Retrospective | Parallel | 33 vs. 29 | IA1–IIA | 220–290 MBq 99mTc- nanocolloid | 4 quadrant | SPECT and low-dose CT, 90 min pi | Dynamic and 4-directional static, 10–90 min pi | Preoperative day | Robot-assisted laparoscopy (with blue dye) |
Belhocine (28) | Prospective | Paired | 7 | IA–IB1 | 37 MBq 99mTc-cysteine rhenium colloid | 2–4 quadrant | SPECT and low-dose CT, directly after lymphoscintigraphy | Dynamic and 4-directional static, timing not specified | Day of surgery | Laparotomy or laparoscopy (with blue dye) |
Bournard (9) | Retrospective | Paired | 42 | IA1–IIA | 60–120 MBq 99mTc-sulfur rhenium colloid | 4 quadrant | SPECT and low-dose CT, 60–120 min pi | Anterior static, 60–120 min pi | Preoperative day or day of surgery | Laparoscopy (with blue dye) |
Klapdor (5) | Prospective | Paired | 51 | IA1–IIIA | 10 MBq 99mTc-nanocolloid | 4 quadrant | No details specified, 30 min pi | No details specified, 30 min pi | Day of surgery | Laparotomy or laparoscopy (with blue dye) |
pi = after injection.