TABLE 1

Biodistribution of 2-⁷⁷Br-BAMP and 4-⁷⁷Br-BAMP in Normal Mice

	Time after injection
Organ	10 min	30 min	1 h	3 h	6 h
2-⁷⁷Br-BAMP
Blood	2.43 ± 0.17	1.28 ± 0.08	0.55 ± 0.19	0.05 ± 0.02	0.00 ± 0.00
Liver	2.93 ± 0.11	1.74 ± 0.59	0.89 ± 0.68	0.13 ± 0.12	0.02 ± 0.01
Kidney	9.89 ± 1.75	6.28 ± 2.44	3.15 ± 0.98	0.47 ± 0.17	0.04 ± 0.04
Intestine	1.64 ± 0.09	1.05 ± 0.13	0.56 ± 0.13	0.20 ± 0.24	0.01 ± 0.00
Spleen	2.98 ± 0.13	1.45 ± 0.11	0.60 ± 0.17	0.00 ± 0.00	0.01 ± 0.03
Pancreas	15.74 ± 1.68	7.03 ± 0.52	3.28 ± 1.32	0.23 ± 0.07	0.00 ± 0.01
Lung	2.33 ± 0.17	1.34 ± 0.36	0.77 ± 0.61	0.02 ± 0.03	0.00 ± 0.01
Heart	2.84 ± 0.15	1.41 ± 0.09	0.74 ± 0.22	0.02 ± 0.04	0.00 ± 0.00
Stomach^*	0.80 ± 0.27	0.38 ± 0.03	0.21 ± 0.05	0.13 ± 0.19	0.01 ± 0.02
Urine^†					90.86 ± 7.07
Feces^†					0.07 ± 0.03
4-⁷⁷Br-BAMP
Blood	4.04 ± 0.04	3.11 ± 0.27	2.96 ± 0.17	2.04 ± 0.31	0.68 ± 0.34
Liver	4.91 ± 0.27	3.92 ± 0.45	3.53 ± 0.23	2.50 ± 0.47	0.83 ± 0.39
Kidney	28.42 ± 6.57	23.98 ± 2.64	22.00 ± 2.67	15.24 ± 3.49	5.32 ± 1.95
Intestine	3.25 ± 1.05	2.32 ± 0.35	1.98 ± 0.10	1.41 ± 0.34	0.45 ± 0.21
Spleen	5.07 ± 0.36	4.29 ± 0.61	3.61 ± 0.23	2.49 ± 0.73	0.77 ± 0.31
Pancreas	30.20 ± 3.46	24.91 ± 4.23	19.37 ± 3.41	13.98 ± 3.67	5.43 ± 3.10
Lung	4.07 ± 0.12	3.39 ± 0.27	3.07 ± 0.10	2.17 ± 0.41	0.69 ± 0.32
Heart	4.36 ± 0.11	4.09 ± 0.42	3.63 ± 0.15	2.45 ± 0.53	0.82 ± 0.33
Stomach^*	1.39 ± 0.28	1.14 ± 0.38	0.94 ± 0.13	0.83 ± 0.20	0.35 ± 0.22
Urine^†					24.22 ± 6.91
Feces^†					3.33 ± 3.26

↵* Each value represents mean percentage injected dose ± SD (n = 5).
↵† Each value represents mean percentage injected dose ± SD (n = 3).
Each value represents mean percentage injected dose per gram of organ ± SD (n = 5).