TABLE 1

Effect of Quantification Method on Level of Statistical Significance in Detecting Differences in ¹¹C-PBR28 Binding

	P (AD vs. HC)
Region	V_T/f_P	SUVR	DVR
Inferior parietal	0.028	<0.0005	<0.00005
Middle and inferior temporal	0.023	<0.0005	<0.00005
Precuneus	NS	0.048^*	0.006
Entorhinal	0.048	0.009	0.001
Parahippocampal	NS	0.006	0.009

↵* Region did not survive regionwise correction for multiple comparisons.
NS = not significant.
P values were derived from univariate ANOVA using diagnosis and TSPO genotype as fixed factors.