Radiation Dose from Low-Dose Protocols for Novel SPECT Scanners
| Study | Rest dose* | Stress dose* | No. of patients | Patient size | Radiotracer | Protocol (1 d) | Study radiation dose (mSv) |
| 24 | 296–481 (8–13) | 462.5; 925–1,332 (12.5; 25–36) | 717 | <91 kg (200 lb) | 99mTc-sestamibi | LD stress only | 4.2 |
| HD stress only | 8.0 | ||||||
| Stress–rest | 11.8 | ||||||
| 61 | 185 (5) | 555 (15) | 131 | BMI, <35 | 99mTc-sestamibi | Rest–stress | 5.8 |
| 62 | 640 (17.29) | 320 (8.65) | 50 | BMI, 19–32 | 99mTc-tetrofosmin | Stress–rest | Stress only, 2.21; stress + rest, 6.62 |
| 52 | 185–222 (5–6) | 370–444 (10–12) | 137 | BMI, 39 ± 7 | 99mTc-tetrofosmin | Stress–rest | 5.10–6.12 |
| 51 | 222 (6) | 740 (20) | 285 | BMI, 29 ± 5 | 99mTc-tetrofosmin | Rest–stress | Rest, 1.4; stress, 4.6 |
| 48 | 129.5 (3.5) | NA | 101 | BMI, 17.1–30.9 | 99mTc-sestamibi | Rest only | 1.2 |
↵* Data are megabecquerels followed by millicuries in parentheses (range or mean).
LD = low dose; HD = high dose; BMI = body mass index (kg/m2; range, mean ± SD, or upper limit); NA = not applicable.
Variable scan times were used for count-based acquisition. The scanner was a Discovery NM/CT 570c (GE Healthcare) (62), D-SPECT (Spectrum Dynamics) (48), or Discovery NM530c (GE Healthcare) (24,51,52,61).