24-Month SUVR Changes with Pontine, Cerebellar, and Cerebral White Matter ROIs*
| ROI | AD Aβ+ | AD Aβ− | P† | MCI Aβ+ | MCI Aβ− | P† | NC Aβ+ | NC Aβ− | P† | NC ε4+ | NC ε4− | P† |
| Pons | −0.000 ± 0.030 | −0.013 ± 0.017 | 0.34 | 0.007 ± 0.028‡ | 0.000 ± 0.018 | 0.02 | 0.014 ± 0.024§ | 0.005 ± 0.017‡ | 0.03 | 0.010 ± 0.019‡ | 0.006 ± 0.019‡ | 0.32 |
| Cerebellum | 0.004 ± 0.064 | 0.011 ± 0.039 | 0.80 | 0.007 ± 0.051 | 0.004 ± 0.023 | 0.33 | 0.024 ± 0.045‡ | 0.006 ± 0.022§ | 0.006 | 0.018 ± 0.039‡ | 0.008 ± 0.025‡ | 0.08 |
| Cerebral white matter | 0.043 ± 0.037§ | 0.019 ± 0.027 | 0.15 | 0.024 ± 0.028§ | 0.008 ± 0.020§ | <0.001 | 0.026 ± 0.021§ | 0.011 ± 0.019§ | 0.001 | 0.020 ± 0.02§ | 0.012 ± 0.021§ | 0.08 |
| White matter vs. pons|| | <0.001 | 0.04 | <0.001 | 0.003 | 0.065 | 0.031 | 0.055 | 0.04 | ||||
| White matter vs. cerebellum|| | 0.01 | 0.69 | 0.02 | 0.13 | 0.86 | 0.15 | 0.85 | 0.19 |
↵* Data are reported as mean ± SD SUVR changes unless otherwise indicated.
↵† P values reflect differences between respective Aβ+ vs. Aβ− or NC APOE4 carrier vs. noncarrier SUVR changes.
↵‡ For within-group SUVR increases, P value was >0.005 but ≤0.05.
↵§ For within-group SUVR increases, P value was ≤0.005.
↵|| Data are reported as P values, which reflect SUVR change differences between use of cerebral white matter vs. pons or between use of cerebral white matter vs. cerebellum in each group.