TABLE 1

Amino Acid Sequences and B1R Binding Affinities of BK and Related Peptides

Peptide	Radiolabel complex–linker	Sequence											Ki (nM)	Reference
BK				Arg	Pro	Pro	Gly	Phe	Ser	Pro	Phe	Arg	5.7^*	29
Kallidin			Lys 1	Arg 2	Pro 3	Pro 4	Gly 5	Phe 6	Ser 7	Pro 8	Phe 9	Arg 10	7.4^*	29
[des-Arg¹⁰]kallidin			Lys	Arg	Pro	Pro	Gly	Phe	Ser	Pro	Phe		9.7^*	29
[Leu⁹,des-Arg¹⁰]kallidin			Lys	Arg	Pro	Pro	Gly	Phe	Ser	Pro	Leu		8.9^†	29
P03083	Ga-DOTA-Ahx		Lys	Arg	Pro	Pro	Gly	Phe	Ser	Pro	Leu		2.6 ± 0.7	23
P03034	Ga-DOTA-dPEG2		Lys	Arg	Pro	Hyp	Gly	Cha	Ser	Pro	Leu		16.0 ± 1.9	23
B9858		Lys	Lys	Arg	Pro	Hyp	Gly	IgI	Ser	D-IgI	Oic		10.1^†	24
B9958		Lys	Lys	Arg	Pro	Hyp	Gly	Cpg	Ser	D-Tic	Cpg		0.089	25
P04158	Ga-DOTA-dPEG2	Lys	Lys	Arg	Pro	Hyp	Gly	IgI	Ser	D-IgI	Oic		1.5 ± 1.9	—
Z02090	Ga-DOTA-dPEG2	Lys	Lys	Arg	Pro	Hyp	Gly	Cpg	Ser	D-Tic	Cpg		1.1 ± 0.8	—

↵* pEC₅₀ (EC₅₀ is the concentration of a drug needed to induce its half-maximal response).
↵† pIC₅₀ (IC₅₀ is the concentration of an inhibitor needed to reduce response by half).