Recommended MPI radiotracer doses for conventional scanners are 8–12 mCi of ^99mTc-sestamibi for rest imaging and 24–36 mCi for stress imaging, 40–60 mCi of ⁸²Rb for 2D imaging and 20 mCi for 3D imaging (58), 20 mCi of ¹³N-ammonia for 2D imaging and 10 mCi for 3D imaging (58), and 2.5–4 mCi for ²⁰¹Tl imaging (59) (1 mCi = 37 MBq). New estimates of ⁸²Rb dose are significantly lower (0.00126 mSv/MBq) (60). Full-dose PET radiotracer is used for 2D imaging and half-dose for 3D imaging; typically, equal dose of radiotracer is administered for rest and for stress PET MPI. Average activities are listed. Estimated dose is effective dose multiplied by administered activity. Dose is calculated for rest and stress scans separately, and if attenuation correction is used, 0.3–0.7 mSv is added for CT and 0.3 mSv for radionuclide transmission scanning (13).