Histology | Biopsies (n) | 18F-FPRGD2 mean SUVmax* | Integrin αvβ3 on tumor cells | Integrin αvβ3 on vessels | Overall integrin αvβ3 on tumor cells and vessels | CD31-MVD | CD105-MVD | PlGF, VEGFs, VEGF receptors 1 and 2 | Ki-67 |
Global | 89 | 3.3 (SD, 1.9) | 0.53 (P < 0.0001) | 0.36 (P = 0.0008) | 0.53 (P < 0.0001) | NS | NS | NS | −0.32 (P = 0.0027) |
ccRCC | 49 | 3.3 (SD, 0.9) | 0.34 (P = 0.0187) | NS | 0.37 (P = 0.0092) | NS | NS | NS | −0.49 (P = 0.0004) |
pRCC | 26 | 2.4 (SD, 1.2) | NS | 0.69 (P = 0.0009) | 0.65 (P = 0.0020) | NS | NS | NS | NS |
↵* Quantification of 18F-FPRGD2 by 1 of 2 observers.
PlGF =placental growth factor; NS = nonsignificant.