Test–Retest Reproducibility of Volume of Distribution
| 2TC, VT (mL/cm3) | MA1, VT (mL/cm3) | MA1, VT/fP (mL/cm3) | |||||||
| Region | aTRV | TRV | ICC | aTRV | TRV | ICC | aTRV | TRV | ICC |
| Amygdala | 9% | 3% ± 11% | 0.39 (-0.18;0.77) | 12% | 5% ± 14% | 0.41 (-0.08;0.74) | 18% | −1% ± 22% | 0.55 (0.11;0.82) |
| Insula | 7% | −1% ± 9% | 0.58 (0.13;0.84) | 7% | 0% ± 9% | 0.68 (0.31;0.87) | 14% | −5% ± 18% | 0.46 (-0.02;0.77) |
| Ant. cingulate cortex | 8% | 0% ± 10% | 0.61 (0.19;0.84) | 6% | 0% ± 8% | 0.78 (0.50;0.92) | 14% | −5% ± 16% | 0.60 (0.17;0.84) |
| Globus pallidus | 8% | 0% ± 10% | 0.70 (0.32;0.89) | 8% | 1% ± 9% | 0.74 (0.41;0.90) | 15% | −4% ± 18% | 0.55 (0.11;0.82) |
| Putamen | 7% | −2% ± 8% | 0.73 (0.37;0.90) | 6% | 0% ± 7% | 0.81 (0.55;0.93) | 13% | −6% ± 16% | 0.57 (0.14;0.83) |
| Temporal cortex | 9% | 0% ± 11% | 0.50 (0.04;0.79) | 7% | 0% ± 8% | 0.70 (0.33;0.88) | 13% | −5% ± 17% | 0.50 (0.04;0.79) |
| Frontal cortex | 8% | 0% ± 10% | 0.61 (0.20;0.84) | 7% | 0% ± 8% | 0.74 (0.41;0.90) | 13% | −5% ± 17% | 0.54 (0.09;0.81) |
| Occipital cortex | 9% | 0% ± 11% | 0.52 (0.06;0.80) | 6% | 1% ± 7% | 0.77 (0.46;0.91) | 13% | −5% ± 16% | 0.52 (0.07;0.80) |
| Hippocampus | 9% | 2% ± 10% | 0.63 (0.22;0.85) | 8% | 2% ± 9% | 0.67 (0.28;0.87) | 15% | −4% ± 18% | 0.54 (0.10;0.81) |
| Caudate | 7% | −2% ± 8% | 0.77 (0.42;0.92) | 6% | 0% ± 7% | 0.82 (0.56;0.93) | 13% | −5% ± 16% | 0.60 (0.18;0.84) |
| Post. cingulate cortex | 9% | 1% ± 11% | 0.72 (0.37;0.89) | 7% | 1% ± 9% | 0.76 (0.45;0.91) | 14% | −5% ± 17% | 0.61 (0.19;0.84) |
| Thalamus | 8% | 0% ± 9% | 0.50 (0.04;0.79) | 7% | 1% ± 9% | 0.54 (0.09;0.81) | 15% | −5% ± 18% | 0.51 (0.05;0.79) |
| Centrum semiovale | 10% | 4% ± 13% | 0.57 (0.12;0.83) | 10% | 3% ± 13% | 0.57 (0.14;0.83) | 18% | −3% ± 20% | 0.52 (0.06;0.80) |
| Cerebellum | 7% | 0% ± 9% | 0.85 (0.63;0.94) | 6% | 1% ± 8% | 0.89 (0.71;0.96) | 13% | −5% ± 17% | 0.64 (0.23;0.85) |
Ant. = anterior; Post. = posterior.
2TC VT estimates with relative SE > 10% or k4 < 0.001 min−1 were excluded from calculation. Data within parentheses are 95% confidence intervals.