Pre-PET Profile of Treatment Monitoring of Systemic Therapy
| Patient characteristic and pre-PET profile | Prostate | Breast | Lung | Other | Combined | Difference between cancer types χ2 P* |
| Total scans (% of cohort) | 1,940 (68.3) | 476 (16.8) | 185 (6.5) | 238 (8.4) | 2,839 (100) | |
| Clinical manifestations at the time of NaF PET | P < 0.0001 | |||||
| Elevated or rising tumor markers† | 709 (36.5) | 181 (38.0) | 94 (50.8) | 101 (42.4) | 1,085 (38.2) | |
| Bone pain | 583 (30.1) | 45 (9.5) | 3 (1.6) | 13 (5.5) | 644 (22.7) | |
| Bone pain and rising tumor marker(s)* | 314 (16.2) | 164 (34.5) | 57 (30.8) | 92 (38.7) | 627 (22.1) | |
| Other imaging findings | 109 (5.6) | 27 (5.7) | 10 (5.4) | 11 (4.6) | 157 (5.5) | |
| Other evidence | 170 (8.8) | 39 (8.2) | 8 (4.3) | 12 (5.0) | 229 (8.1) | |
| None | 55 (2.8) | 20 (4.2) | 13 (7.0) | 9 (3.8) | 97 (3.4) | |
| Pre-PET summary stage (%) | P < 0.0001 | |||||
| No evidence of disease | 73 (3.8) | 38 (8.0) | 7 (3.8) | 10 (4.2) | 128 (4.5) | |
| Local | 160 (8.2) | 8 (1.7) | 15 (8.1) | 15 (6.3) | 198 (7.0) | |
| Regional | 53 (2.7) | 6 (1.3) | 16 (8.6) | 1 (0.4) | 76 (2.7) | |
| Single distant metastases | 168 (8.7) | 54 (11.3) | 20 (10.8) | 26 (10.9) | 268 (9.4) | |
| Multiple distant metastases | 1,082 (55.8) | 311 (65.3) | 118 (63.8) | 159 (66.8) | 1,670 (58.8) | |
| Unknown | 404 (20.8) | 59 (12.4) | 9 (4.9) | 27 (11.3) | 499 (17.6) | |
| Pre-PET suspected response (%) | P < 0.0001 | |||||
| Probable complete response | 105 (5.4) | 56 (11.8) | 14 (7.6) | 22 (9.2) | 197 (6.9) | |
| Possible partial response | 972 (50.1) | 252 (52.9) | 103 (55.7) | 134 (56.3) | 1,461 (51.5) | |
| Suspect no response | 212 (10.9) | 79 (16.6) | 34 (18.4) | 49 (20.6) | 374 (13.2) | |
| Suspect progression | 651 (33.6) | 89 (18.7) | 34 (18.4) | 33 (13.9) | 807 (28.4) | |
| Pre-PET treatment plan (%) | P < 0.0001 | |||||
| Continue current treatment | 1,211 (62.4) | 365 (76.7) | 141 (76.2) | 194 (81.5) | 1,911 (67.3) | |
| Modify dose or schedule | 145 (7.5) | 26 (5.5) | 14 (7.6) | 15 (6.3) | 200 (7.0) | |
| Switch to another treatment | 571 (29.4) | 81 (17.0) | 28 (15.1) | 25 (10.5) | 705 (24.8) | |
| Stop treatment and switch to supportive care | 13 (0.7) | 4 (0.8) | 2 (1.1) | 4 (1.7) | 23 (0.8) | |
| Comparison with prior bone imaging | P < 0.0001 | |||||
| Comparison made (%) | 1,520 (78.4) | 362 (76.1) | 120 (64.9) | 158 (66.4) | 2,160 (76.1) | |
| Conventional BS (%) | 423 (21.8) | 71 (14.9) | 11 (5.9) | 25 (10.5) | 530 (18.7) | |
| NaF PET scan (%) | 1,097 (56.5) | 291 (61.1) | 109 (58.9) | 133 (55.9) | 1,630 (57.4) | |
| No comparison made (%) | 420 (21.6) | 114 (23.9) | 65 (35.1) | 80 (33.6) | 679 (23.9) |