TABLE 4

Association Between PET/CT- and CT-Based Tumor Parameters and Survivals Using Cox Regression Model

	OS			DFS			NRFS
Variable	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
TNM classification
T stage
T1–2 vs. T3–4	2.68	1.27–5.64	0.01	3.63	1.75–7.50	0.001	2.40	0.90–6.46	0.07
N stage
N1–2 vs. N3	1.40	0.36–4.50	0.71	1.34	0.4–4.03	0.60	1.25	0.21–3.01	0.56
N1 vs. N2–3	1.02	0.40–2.62	0.98	1.09	0.44–2.74	0.85	1.43	0.38–5.40	0.60
CT-related parameters for MNN
Central necrosis, no vs. yes	2.59	1.13–5.26	0.02	3.62	1.79–7.35	<0.001	10.99	2.56–47.62	0.001
Maximal diameter (cm), <2.4 vs. ≥2.4	1.24	0.48–3.27	0.66	2.16	0.78–6.01	0.14	1.80	0.55–5.92	0.34
N-GTV (mL), <8.9 vs. ≥8.9	1.56	0.21–1.91	0.42	1.01	0.41–2.47	0.98	1.02	0.25–4.22	0.98
PET/CT-related parameters
N-TLG40% (g), <38.0 vs. ≥38.0 g	1.71	0.77–3.78	0.19	2.12	1.13–4.00	0.02	2.63	1.10–6.30	0.03
N-SUV_max, <6.1 vs. ≥6.1	1.68	0.72–3.92	0.23	1.36	0.55–3.36	0.51	1.57	0.22–1.80	0.40
N-MTV2.5 (mL), <3.0 vs. ≥3.0	1.62	0.75–3.50	0.22	1.20	0.57–2.56	0.64	1.19	0.51–2.75	0.69
T-TLG40% (g), <53.3 vs. ≥53.3	1.09	0.47–2.09	0.97	1.75	0.71–4.32	0.22	1.72	0.70–4.24	0.24
T-SUV_max, <10.7 vs. ≥10.7	1.39	0.61–3.22	0.43	1.55	0.58–4.09	0.38	1.67	0.64–4.33	0.29
T-MTV2.5 (mL), <14.5 vs. ≥14.5	2.43	0.99–6.05	0.06	1.11	0.38–2.72	0.88	0.93	0.36–2.42	0.88
Primary tumor origin, oropharynx vs. hypopharynx	1.11	0.56–2.17	0.77	0.99	0.47–2.13	0.99	0.98	0.46–2.09	0.95

T-TLG40% = pretreatment primary TLG defined by 40% of SUV_max; T-SUV_max = pretreatment maximum SUV of primary tumor; T-MTV2.5 = pretreatment primary metabolic tumor volume defined by SUV = 2.5.
This study used median values of T-SUV_max, T-MTVs, and T-TLGs as cutoff points.