Diagnostic Value of 18F-FDG PET and 18F-FDG PET/CT for Staging and Restaging of Pediatric Patients with Malignant Sarcomas
| Study | No. of disease cases | Patients (n) | Timing | Included lesions | Sensitivity | Specificity | PPV | NPV |
| Völker (78) | 23 ESFT, 11 OS, 12 RMS | 46 | Initial staging | Nodal lesions | 88% | 97% | 88% | 97% |
| Bone lesions | 100% | 91% | 83% | 100% | ||||
| Lung lesions | 56% | 100% | 100% | 90% | ||||
| Tateishi (77) | 20 ES, 18 OS, 5 SynS, 3 RMS, 1 FS, 1 EpS, 1 PleoMFH, 1 AS | 50 | Initial staging | Nodal lesions | 85.71% | 97.7% | 85.7% | 97.7% |
| Distant metastases | 70.8% | 100% | 100% | 78.8% | ||||
| Federico (71) | 30 RMS | 30 | Initial staging | Nodal lesions | 93.75% | 100% | 100% | 95.24% |
| Eugene (79) | 23 RMS | 23 | Initial staging | Nodal lesions | 100% | 100% | 100% | 100% |
| Distant metastases | 100% | 91% | 60% | 100% | ||||
| Arush (95) | 9 ES, 3 OS, 7 RMS | 19 | Follow-up | Local recurrence | 100% | 92% | 88% | 100% |
| Distant metastasis | 77% | 83% | 91% | 63% | ||||
| London (3) | 20 ES, 21 OS | 41 | All | All lesions | 81.8% | 97.5% | 79.4% | 97.8% |
| Mody (133) | 16 ESFT, 9 RMS | 25 | All | All lesions | 86% | 80% | 89% | 67% |
| Walter (81) | 12 ES, 9 OS, 8 STS | 29 | All | Bone lesions | 100% | 100% | 100% | 100% |
PPV = positive predictive value; NPV = negative predictive value; ESFT = Ewing sarcoma family tumors; OS = osteosarcoma; RMS = rhabdomyosarcoma; ES = Ewing sarcoma; SynS = synovial sarcoma; FS = fibrosarcoma; EpS = epithelioid sarcoma; PleoMFH = pleomorphic malign fibrous histiocytoma; AS = angiosarcoma; STS = soft-tissue sarcoma.