TABLE 3

Literature Review

Authors	Patients (n)	LR (n)	Time of ¹⁸FDG PET/CT	Registration	Indices*	Defined and compared volumes^†	Results
Aerts (▪)	17	—	A: d0	Rigid ± manual	OF	A_{34–40–50–60–70–80}	OF_34–60>0.70
			B: Per-RT d7			B_{34–40–50–60–70–80}	OF_70–80>0.50
			C: Per-RT d14			C_{34–40–50–60–70–80}
Abramyuk (8)	10	10	A: Pre-RT	?	Visual	A₃₅	R visually included in A₃₅
			R: Post-RT m6–9			R automatic (ROVER)	Threshold: 35% SUV_max
Aerts (▪)	55	22	A: Pre-RT	Rigid ± manual	OF	A_{34–40–50–60–70}	OF A₅₀∩R_>aorta = 0.70
			R: Post-RT m3			R_70–80–90	OF A₅₀∩R₈₀ = 077
						R_>aorta; R_>2.5; R_>5	OF A₅₀∩R₉₀ = 0.84
							Threshold: 50% SUVmax
Aerts (▪)	12	7	A: Pre-RT	Rigid ± manual	OF	A_{34–40–50–60–70}	OF A₅₀∩R_>aorta = 0.68
			R: Post-RT m3			R_70–80–90	OF A₅₀∩R₉₀ = 0.74
						R_>aorta	Threshold: 50% SUVmax
Shusharina (11)	61	17	A: Pre-RT	Nonrigid	OF	A₅₀	OF A₅₀∩R_d10 = 0.80
			R: Post-RT d10	Derived		R₈₀	OF A₅₀∩R_m3 = 0.63
			R: Post-RT m3	Transformation			OF A₅₀∩R_m6 = 0.38
			R: Post-RT m6	Matrix			Threshold: 50% SUVmax
Present study	39	17	A: Pre-RT	Rigid ± manual	Dice	A_{30–40–50–60–70–80–90}	A₇₀∩R₄₀/A₇₀ = OF A₇₀∩R₄₀ = 0.67
			B: d0		Jaccard	B₄₀ and _B90	A₇₀∩R₉₀/R₉₀ = OF A₇₀∩R₉₀ = 0.56
			C: Per-RT d21		OF	C₄₀ and _C90	A₆₀∩R₉₀/R₉₀ = OF A₆₀∩R₉₀ = 0.68
			R: Post-RT m3–12		A∩R/A	R₄₀ and _R90	Threshold: 70% SUVmax
					A∩R/R

*Overlap quantification.
^†Numeric indices refer to threshold for delineation.
d = days after radiotherapy began; m = months after radiotherapy began; OF = overlap fraction; RT = radiotherapy.
Threshold refers to recommended threshold for hot-spot delineation.