TABLE 2

In Vitro Affinity of AMC20 Toward Dopamine Receptor Subtypes

D2LongD2ShortD3
LigandD1HighLowKiLow/KiHighHighLowHighLow
AMC205,0620.08584988253990.6219
FBu-AMC13*6,9125.680.514.41.392.7—†12.1
AMC1*7,2532.987023.540736—3.2
(−)NPA*—0.0751.7323.10.110.6—1.91
(+)PHNO*—0.4521.447.6n.d.19—1.08
Dopamine*—23111,58150n.d.920—24.8

  • ↵* Data from van Wieringen et al. (15).

  • ↵† No high-affinity component detected.

  • All values are mean Ki values (≥3 independent experiments) in nM.

  • KiLow = inhibition constant for low-affinity state; KiHigh = inhibition constant for high-affinity state.